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. 2022 Jul 13;13:291. doi: 10.1186/s13287-022-02963-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — ADSC-sEVs treatment improved functional recovery and attenuated neuronal apoptosis following SCIRI. a Basso Mouse Scale (BMS) values at different times after SCIRI. b The inclined plane test at different times after SCIRI. c Representative images of the footprint assay performed 28 days after SCIRI. d Photographs of the swimming test conducted 28 days after SCIRI and statistical analysis of the Louisville Swim Scale. e Dil-sEVs accumulated in the injury area of spinal cord. f Analysis of apoptosis of neurons following SCIRI with the TUNEL assay. g Quantification of apoptosis rate in each experimental group. h Expression of apoptosis-related proteins following SCIRI as determined using Western blotting assay. i Relative expression levels of apoptosis-related proteins normalized to GAPDH. *p < 0.05 compared with the Sham group, ^#p < 0.05 compared with the SCIRI group