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. 2022 Jul 13;13:291. doi: 10.1186/s13287-022-02963-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — ADSC-sEVs transported TSG-6 proteins into spinal cord tissue and overexpression of TSG-6 enhanced the capacity of sEVs to improve motor function after SCIRI. a. Expression of TSG-6 expression in spinal cord tissue after ADSC-sEVs administration as determined by Western blotting analysis. b Relative expression levels of TSG-6 in spinal cord tissues, normalized to GAPDH. c Expression of TSG-6 in ADSC-sEVs as determined by Western blotting assay. d, e Determination of TSG-6 expression in Lenti-TSG-6-sEVs and Lenti-Ctrl-sEVs by Western blotting assay. f, g Values of Basso Mouse Scale (BMS) and inclined plane test at different times after SCIRI. h Representative images of the footprint assay performed 28 days after SCIRI. *p < 0.05 compared with the SCIRI group, ^#p < 0.05 compared with the Lenti-Ctrl-sEVs group