Table 2.

Association of previously reported GWAS height SNPs with height in Taiwan

No.	rs ID	Gene	Chr.	Position	Minor allele	Major allele	Risk allele	Training group (N = 67,452) (p < 0.05/1722)				Testing group (N = 14,454)
								Beta	95% CI		P-value	Beta	95% CI		P-value
1	rs2300092	MTOR	1	11206407	T	C	T	0.027	0.014	0.039	2.62E−05	0.024	−0.003	0.050	8.51E−02
2	rs3014240	CCDC17	1	45623553	C	G	C	0.025	0.015	0.036	9.06E−07	0.032	0.010	0.054	4.17E−03
3	rs2666504		1	62169409	C	T	C	0.024	0.013	0.034	5.80E−06	0.015	−0.007	0.037	1.84E−01
4	rs11205303	MTMR11	1	149934520	C	T	C	0.057	0.047	0.067	5.69E−28	0.033	0.011	0.055	3.26E−03
5	rs6587515		1	150636412	A	G	A	0.026	0.014	0.037	2.27E−05	0.018	−0.008	0.043	1.71E−01
6	rs1325596	PAPPA2	1	176824930	G	A	A	0.032	0.021	0.044	6.10E−08	0.043	0.018	0.068	9.05E−04
7	rs10911212	LAMC1	1	183055334	C	T	C	0.024	0.014	0.034	2.83E−06	0.007	−0.015	0.029	5.30E−01
8	rs4472734	PTPN14	1	214444842	C	T	C	0.028	0.018	0.037	4.96E−08	0.013	−0.009	0.034	2.48E−01
9	rs10165255	CYS1	2	10059474	A	G	A	0.030	0.016	0.044	1.70E−05	0.037	0.008	0.066	1.30E−02
10	rs6735681		2	15983051	T	C	T	0.023	0.013	0.033	5.34E−06	0.014	−0.007	0.036	1.98E−01
11	rs780094	GCKR	2	27518370	T	C	C	0.022	0.012	0.031	1.69E−05	0.025	0.004	0.046	2.22E−02
12	rs3755206	CRIM1	2	36456285	G	T	T	0.054	0.042	0.067	7.94E−17	0.054	0.026	0.081	1.35E−04
13	rs6544743	LOC102723904	2	44163230	T	G	T	0.024	0.013	0.035	1.52E−05	0.005	−0.018	0.029	6.55E−01
14	rs3791675	EFEMP1	2	55884174	C	T	C	0.075	0.064	0.087	2.78E−37	0.072	0.047	0.097	2.06E−08
15	rs1432559	LOC105374690	2	55962483	G	T	G	0.055	0.030	0.080	1.32E−05	0.073	0.019	0.126	8.21E−03
16	rs4241349	ANTXR1	2	69103152	G	A	G	0.026	0.014	0.037	9.55E−06	0.039	0.015	0.064	1.78E−03
17	rs76709099	IHH	2	219055182	A	C	C	0.064	0.047	0.080	8.72E−14	0.061	0.025	0.097	9.16E−04
18	rs2564923		3	53069246	A	G	A	0.027	0.016	0.038	1.49E−06	0.034	0.011	0.058	4.25E−03
19	rs9841212		3	134473096	C	T	T	0.024	0.013	0.036	2.79E−05	0.003	−0.021	0.027	8.10E−01
20	rs1055153	WWTR1	3	149657086	T	G	G	0.046	0.030	0.062	1.33E−08	0.013	−0.022	0.047	4.69E−01
21	rs6774762	GHSR	3	172447200	G	A	A	0.037	0.024	0.050	1.80E−08	0.032	0.005	0.060	2.16E−02
22	rs7697556		4	72649596	C	T	T	0.037	0.027	0.047	1.77E−13	0.030	0.009	0.051	5.37E−03
23	rs17017911	GUSBP5	4	143559481	G	A	A	0.022	0.012	0.032	2.19E−05	0.016	−0.005	0.038	1.40E−01
24	rs6845999	HHIP-AS1	4	144644674	T	C	T	0.058	0.046	0.070	7.29E−22	0.062	0.037	0.088	1.52E−06
25	rs4240326		4	144918112	A	G	A	0.028	0.017	0.039	7.17E−07	0.018	−0.006	0.042	1.50E−01
26	rs301901	NIPBL	5	37046524	A	G	A	0.024	0.014	0.034	2.04E−06	0.016	−0.005	0.038	1.32E−01
27	rs4865956		5	55586677	T	A	T	0.024	0.014	0.035	5.07E−06	0.018	−0.005	0.040	1.22E−01
28	rs7706662	CEP120	5	123419868	T	C	C	0.023	0.013	0.032	7.16E−06	−0.014	−0.035	0.008	2.09E−01
29	rs2908532		5	142242319	A	C	A	0.027	0.016	0.037	1.23E−06	0.010	−0.013	0.033	3.93E−01
30	rs2974438	SLIT3	5	168823898	A	G	G	0.030	0.017	0.043	3.53E−06	0.020	−0.008	0.047	1.61E−01
31	rs12153391	SMIM23	5	171776434	A	C	C	0.029	0.019	0.039	1.22E−08	0.016	−0.006	0.038	1.46E−01
32	rs4868126		5	171856465	T	G	G	0.031	0.020	0.041	4.13E−09	0.041	0.019	0.063	2.39E−04
33	rs722585	GMDS, HCG17	6	1775629	A	G	G	0.023	0.013	0.034	1.61E−05	0.060	0.037	0.083	3.26E−07
34	rs78566116		6	32428369	T	G	G	0.040	0.022	0.057	5.70E−06	0.039	0.002	0.075	3.87E−02
35	rs2780226		6	34231315	C	T	C	0.095	0.079	0.110	1.75E−32	0.072	0.038	0.106	2.87E−05
36	rs12209223	FILIP1, LOC101928540	6	75454873	A	C	A	0.050	0.033	0.067	1.02E−08	0.057	0.020	0.095	2.76E−03
37	rs648831	BCKDHB	6	80246491	C	T	T	0.024	0.014	0.034	1.53E−06	0.017	−0.004	0.038	1.22E−01
38	rs3805859	BCKDHB	6	80339229	C	A	C	0.025	0.015	0.035	5.62E−07	0.017	−0.005	0.038	1.23E−01
39	rs113898003	L3MBTL3	6	130020090	C	T	T	0.042	0.032	0.052	4.72E−16	0.045	0.023	0.068	5.45E−05
40	rs7765757	EPB41L2	6	131050608	C	T	T	0.038	0.022	0.053	1.29E−06	0.038	0.006	0.070	2.12E−02
41	rs3020359	ESR1	6	152044128	T	C	C	0.023	0.013	0.033	1.11E−05	0.035	0.013	0.057	1.78E−03
42	rs73029259	LOC107986666	6	163690316	A	T	A	0.037	0.020	0.054	1.99E−05	0.033	−0.004	0.069	7.95E−02
43	rs57246313		7	25850077	A	G	A	0.024	0.014	0.034	3.01E−06	0.026	0.004	0.048	1.93E−02
44	rs1007358		7	46161757	G	A	G	0.036	0.023	0.049	1.12E−07	0.041	0.012	0.069	5.43E−03
45	rs42377	CDK6	7	92614358	A	G	A	0.035	0.019	0.052	2.44E−05	0.007	−0.029	0.042	7.15E−01
46	rs445	CDK6	7	92779056	T	C	C	0.025	0.015	0.035	1.86E−06	0.029	0.007	0.050	1.08E−02
47	rs76364830	DLC1	8	13514611	A	G	G	0.041	0.023	0.059	9.41E−06	0.059	0.019	0.098	3.93E−03
48	rs10958476	PLAG1	8	56183249	C	T	C	0.030	0.017	0.042	2.60E−06	0.014	−0.013	0.041	3.04E−01
49	rs7842996		8	77194904	A	T	A	0.031	0.019	0.043	6.50E−07	0.033	0.007	0.060	1.47E−02
50	rs7817087		8	116552698	A	G	G	0.026	0.016	0.035	4.15E−07	0.010	−0.012	0.031	3.81E−01
51	rs6992491		8	128185657	G	C	G	0.022	0.012	0.032	1.68E−05	0.011	−0.011	0.033	3.22E−01
52	rs10120219	LOC105376158	9	95602265	C	T	T	0.036	0.026	0.046	7.29E−13	0.040	0.018	0.061	2.77E−04
53	rs34575265		9	106181520	T	C	C	0.022	0.012	0.032	2.66E−05	0.011	−0.011	0.033	3.16E−01
54	rs7858562	ZNF483, PTGR1	9	111562668	G	A	A	0.025	0.014	0.037	2.33E−05	0.035	0.009	0.060	7.19E−03
55	rs12344818		9	115728289	T	C	C	0.031	0.019	0.043	1.73E−07	−0.006	−0.031	0.020	6.65E−01
56	rs3789280	PAPPA	9	116191093	A	T	A	0.036	0.020	0.053	1.23E−05	0.018	−0.018	0.053	3.30E−01
57	rs12338076	QSOX2	9	136229894	C	A	C	0.040	0.029	0.050	3.63E−13	0.045	0.022	0.068	1.50E−04
58	rs779933	ZMIZ1	10	79158760	A	G	G	0.028	0.017	0.039	8.37E−07	0.038	0.014	0.062	2.22E−03
59	rs2648725	PCGF5	10	91255322	A	T	A	0.044	0.024	0.064	1.61E−05	0.052	0.009	0.095	1.77E−02
60	rs1938679		11	69457328	T	C	C	0.038	0.029	0.048	2.98E−14	0.032	0.010	0.053	3.84E−03
61	rs645935	SERPINH1	11	75568245	C	T	T	0.042	0.032	0.051	9.90E−17	0.034	0.012	0.055	2.03E−03
62	rs59917308		12	56264924	T	C	T	0.069	0.039	0.099	5.37E−06	−0.005	−0.069	0.059	8.81E−01
63	rs3816804	CS	12	56286961	T	C	C	0.112	0.099	0.126	6.35E−63	0.114	0.085	0.142	3.14E−15
64	rs2277339	PRIM1	12	56752285	G	T	T	0.037	0.025	0.049	1.81E−09	0.040	0.014	0.066	2.91E−03
65	rs10747784		12	57857579	G	A	G	0.027	0.015	0.038	4.71E−06	0.019	−0.005	0.044	1.21E−01
66	rs10878984		12	69434754	C	T	T	0.044	0.034	0.054	5.99E−17	0.025	0.003	0.047	2.84E−02
67	rs3847787	CRADD	12	93813756	G	A	G	0.022	0.012	0.033	1.91E−05	0.031	0.009	0.053	6.20E−03
68	rs2093210	C14orf39	14	60490561	T	C	C	0.043	0.031	0.055	2.54E−12	0.027	0.001	0.053	4.52E−02
69	rs910316	TMED10	14	75159339	A	C	A	0.029	0.016	0.042	1.20E−05	0.030	0.002	0.058	3.67E−02
70	rs7156335	ITPK1	14	92939887	C	T	C	0.049	0.028	0.070	4.46E−06	0.033	−0.013	0.080	1.56E−01
71	rs12592845		15	48392761	T	C	C	0.028	0.015	0.041	1.99E−05	0.065	0.037	0.093	5.11E−06
72	rs975210	TLE3	15	70072013	A	G	A	0.033	0.019	0.048	7.70E−06	0.004	−0.028	0.036	8.25E−01
73	rs750460	LOXL1	15	73949165	A	G	G	0.047	0.031	0.063	1.16E−08	0.048	0.012	0.083	8.87E−03
74	rs8025068	ARID3B	15	74577704	G	T	G	0.023	0.013	0.032	6.66E−06	0.028	0.006	0.049	1.10E−02
75	rs4467054	ADAMTS17	15	100255167	G	T	G	0.029	0.018	0.039	9.87E−08	0.038	0.014	0.061	1.45E−03
76	rs258324	CDK10	16	89687847	T	G	T	0.043	0.032	0.054	1.97E−15	0.046	0.023	0.069	1.13E−04
77	rs74494415	GALR1	18	77260182	T	C	C	0.040	0.022	0.058	8.97E−06	0.026	−0.013	0.064	1.88E−01
78	rs1741344		20	4121153	C	T	C	0.032	0.019	0.044	3.37E−07	0.040	0.014	0.067	2.99E−03
79	rs967417		20	6640246	G	A	G	0.033	0.020	0.046	1.10E−06	0.040	0.011	0.068	5.95E−03
80	rs3213180	E2F1	20	33675818	C	G	G	0.032	0.022	0.043	1.83E−09	0.043	0.020	0.066	2.71E−04
81	rs143384	GDF5	20	35437976	G	A	G	0.074	0.063	0.085	3.61E−40	0.056	0.032	0.079	4.19E−06
82	rs2235363	ZHX3	20	41179129	G	A	G	0.023	0.013	0.032	7.22E−06	0.011	−0.010	0.032	3.10E−01
83	rs11537645	UBE2C	20	45812764	G	C	C	0.044	0.026	0.061	1.45E−06	0.008	−0.031	0.046	7.01E−01

SNP, single nucleotide polymorphism; GWAS, genome-wide association study; No., number; Chr., chromosome; 95% CI, 95% confidence interval

The measured (phenotypic) heights (cm) were stratified by sex, mean-centered, and normalized to one standard deviation (SD) before height GWAS analysis

Beta-value calculation was performed in agreement with the defined risk alleles