. 2022 Jul 12;22:1333. doi: 10.1186/s12889-022-13727-3

Table 1.

Trends in Age-Adjusted Thyroid Cancer Incidence Rates by Demographic factors, 2000–2017

	2000–2017		Incidence Rate cases/100000 PY				Trend 1/ Trend 3			Trend 2/ Trend 4				2000–2017
Demographic factors	No of new cases	Age adjusted/ 100 000 (95% CI)	2000	2009	2015	2017	Years	APC (95%CI)	P Value	Years	APC (95%CI)	P Value		AAPC (95%CI)	P Value
Overall	683,157	12.1(12.1,12.1)	7.4	13.6	14.7	13.2	2000–2009	7.3^a (6.8, 7.7)	< 0.001	2009–2015	1.6^a (0.9, 2.3)	< 0.001		3.6^a (3.2, 4.1)	< 0.05
							2015–2017	-5.8^a (-8.7, -2.8)	0.002
Sex
Female	514,414	17.9(17.8,17.9)	10.9	20.1	21.8	19.4	2000–2009	7.2^a (7.0, 7.5)	< 0.001	2009–2012	2.3^a (0.6, 4.2)	0.017		3.6^a (3.2, 4.0)	< 0.05
							2012–2015	0.5 (-1.1, 2.2)	0.468	2015–2017	-5.6^a (-7.3, -3.9)	< 0.001
Male	168,743	6.2(6.1,6.2)	3.9	6.9	7.4	6.9	2000–2009	6.9^a (6.2, 7.7)	< 0.001	2009–2014	2.0^a (0.4, 3.7)	0.021		3.8^a (3.1, 4.5)	< 0.05
							2014–2017	-2.3 (-4.8, 0.2)	0.068
Race/ethnicity
AI/AN	3719	9.0 (8.7,9.3)	4.8	9.6	11.2	10.8	2000–2013	7.3^a (6.1, 8.6)	< 0.001	2013–2017	-1.7 (-6.7, 3.6)	0.493		5.1^a (3.7, 6.6)	< 0.05
API	37,351	13.2 (13.0,13.3)	8.6	14.1	15.9	14.3	2000–2003	2.3^a (0.4, 4.3)	0.025	2003–2009	7.4^a (6.7, 8.1)	< 0.001		3.1^a (2.7, 3.5)	< 0.05
							2009–2014	2.8^a (2.1–3.5)	< 0.001	2014–2017	-3.9^a (-4.9, -2.8)	< 0.001
Blacks	49,909	7.8 (7.7,7.9)	4.9	8.5	9.6	8.1	2000–2013	5.8^a (5.2, 6.5)	< 0.001	2013–2017	-5.4^a (-8.0, -2.6)	0.001		3.1^a (2.3, 3.9)	< 0.05
Whites	506,759	12.9 (12.9,13.0)	7.9	14.8	15.8	14.2	2000–2009	7.5^a (7.1, 8.0)	< 0.001	2009–2015	1.3^a (0.5, 2.1)	0.003		3.7^a (3.2–4.2)	< 0.05
							2015–2017	-5.7a (-8.9, -2.3)	0.004
Hispanic	77,526	11.4 (11.3,11,5)	7.0	12.1	13.8	12.9	2000–2009	6.3^a (5.5, 7.1)	< 0.001	2009–2015	2.5* (1.1, 3.8)	0.002		3.7^a (2.9–4.6)	< 0.05
							2015–2017	-3.4 (-8.7, 2.2)	0.199
Age (years)
< 30	68,650	2.9 (2.9–2.9)	2.1	3.0	3.5	3.3	2000–2015	3.8^a (3.5, 4.2)	< 0.001	2015–2017	-5.5 (-12.4, 1.9)	0.128	2.7^a (1.8, 3.6)		< 0.05
30–44	183,261	16.3 (16.3,16.4)	10.3	17.3	20.8	18.7	2000–2006	6.1^a (5.0, 7.2)	< 0.001	2006–2009	8.3^a (3.0, 14.0)	0.007	3.6^a (2.6, 4.6)		< 0.05
							2009–2015	2.0^a (0.9, 3.0)	0.003	2015–2017	-5.3^a (-9.5, -0.8)	0.027
45–59	229,817	20.8 (20.7–20.9)	12.3	21.8	25.2	22.7	2000–2009	7.5^a (7.1, 8.0)	< 0.001	2009–2014	2.0^a (0.9, 3.1)	0.002	3.8^a (3.4, 4.3)		< 0.05
							2014–2017	-3.6^a (-5.3, -1.9)	0.001
60–74	150,976	22.3 (22.2–22.5)	12.4	25.6	25.8	23.0	2000–2008	9.4^a (8.5, 10.2)	< 0.001	2008–2013	2.1^a (0.4, 3.8)	0.018	4.1^a (3.4, 4.7)		< 0.05
							2013–2017	-3.5^a (-5.0, 2.0)	< 0.001
≥ 75	50,453	15.5 (15.3–15.6)	10.1	17.8	17.3	15.7	2000–2008	7.7^a 6.8,8.5)	< 0.001	2008–2014	0.8^a (-0.5,2.2)	0.210	3.0^a (2.2,3.7)		< 0.05
							2014–2017	-4.7^a (-7.6,-1.7)	0.006

^aThe difference was statistically significant