Table 3.
Execution time of methods in seconds. T, student t-test; LR, linear regression; ROC, receiver operating characteristic; FC, fold change
| Method | MCA-Spleen | MCA-Lung | Human-Lung &PBMC | Human-BM | Human-PBMC |
|---|---|---|---|---|---|
| COMET | 233,760.604 | 2,143,037.250 | Failed | Failed | Failed |
| COMET + DB | 297.737 | 1,837.851 | 260.130 | 383.059 | Failed |
| CombiROC + DB | 53.112 | 385.255 | 2130.589 | 2080.815 | 16854.740 |
| MAST | 335.188 | 2,584.087 | 418.121 | 615.921 | 13,457.332 |
| MAST + DB | 24.285 | 173.521 | 29.920 | 46.128 | 918.817 |
| Wilcoxon | 84.161 | 563.938 | 260.130 | 383.059 | 16,507.774 |
| Wilcoxon + DB | 7.623 | 32.223 | 43.817 | 24.566 | 938.315 |
| T | 59.072 | 367.252 | 162.578 | 243.478 | 3,634.189 |
| T + DB | 7.555 | 27.483 | 17.432 | 16.956 | 253.804 |
| LR | 285.929 | 3,107.313 | 464.449 | 684.169 | 11,372.861 |
| LR + DB | 18.368 | 174.837 | 29.061 | 40.596 | 701.804 |
| ROC | 315.340 | 1,015.340 | 491.229 | 723.092 | 13,321.247 |
| ROC + DB | 26.295 | 74.471 | 33.701 | 47.456 | 1052.457 |
| FC | 57.330 | 215.132 | 108.760 | 176.104 | 554.331 |
| FC + DB | 4.591 | 14.944 | 7.633 | 13.098 | 40.919 |
| RankCorr | 388.149 | 585.558 | 448.422 | 618.094 | 21654.163 |
| RankCorr + DB | 67.956 | 127.577 | 125.301 | 160.225 | 5398.131 |
| sc2marker | 277.122 | 3,150.673 | 368.844 | 240.640 | 17,570.998 |
| sc2marker + DB | 17.031 | 79.344 | 35.184 | 22.283 | 184.119 |