Fig. 10.

Phosphorylated TDP-43 (p-TDP-43) level in the cerebral cortex of MHV-1-infected mice. Normal (control) brain illustrates the basal level of p-TDP-43 in the brain cortex. Note the marked increase in levels of p-TDP-43 in MHV-1-infected brains (MHV-1) and such increase in p-TDP-43 was reduced when these mice were treated with the peptide drug SPIKENET (5 mg/kg) (MHV-1 + SPIKENET) (n = 3). Scale bar = 35 µm. Blue, nuclear stain DAPI