Fig. 2.

Long-term clinical signs in MHV-1-infected mice. MHV-1-inoculated mice exhibit severe illness in the acute phase (stages IV–VI, from 7 to 12 days), while the animal sickness was significantly reduced to stages II after 12 months. Furthermore, SPIKENET (SPK, 5 mg/kg, 3 doses on days 2, 4, and 6 post-MHV-1 inoculation) prevented such effect in both acute phase and after long-term post-infection