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. 2022 Jul 13;59(10):5970–5986. doi: 10.1007/s12035-022-02932-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Acute and long-term changes in kidney post-MHV-1 coronavirus infection. A Normal mouse kidney. B Representative image from “MHV-1-infected mouse kidney showed tubular epithelial cell degenerative changes, peritubular vessel congestion, proximal and distal tubular necrosis, hemorrhage in interstitial tissue, and vacuolation of renal tubules were observed in MHV-1 exposed mice kidneys at 7 days post-infection” [1]. (V). C MHV-1-infected mouse kidney (12 months post-infection). F–H, enlarged images of C, shows congested blood vessels (black arrow), distal tubular damage (yellow arrows), fibrosis and inflamed glomeruli (asterisks), necrosis (green arrows), loss of podocytes (white arrow), degenerating tubules (black asterisks), hyaline casts (pink arrows), loss of tubular epithelial cells (karyolysis) (dagger symbol) and Karyorrhexis (light blue arrow). D and E Treatment of MHV-1-infected mice with the peptide drug SPIKENET (5 mg/kg) ameliorated the above-mentioned changes at day 7 and 12 months post-infection, respectively (n = 3). (H&E, original magnification 400 × (A-E), and F–H are enlarged images of C)