Fig. 8.

Increased cortical astrogliosis post-MHV-1 coronavirus infection. Representative image from MHV-1 infected mouse (12 months) brain cortex showed severe reactive astrocytes (astrogliosis, green, glial fibrillary acidic protein, GFAP, in MHV-1), as compared to normal mice brain cortex (control). Note, such an increase in astrogliosis was reduced when these mice were treated with the peptide drug SPIKENET (5 mg/kg) (MHV-1 + SPIKENET) (n = 3). Scale bar = 35 µm. Blue, nuclear stain DAPI