TABLE 1.
Clinical and Pathologic Details of the 7 Study Cases Showing IHC Positivity for SARS-CoV-2 Spike Antigen
| Case 1 | Case 2 | Case 3 | Case 4 | Case 5 | Case 6 | Case 7 | |
|---|---|---|---|---|---|---|---|
| Extent (% or # of foci, maximum size) | Diffuse (50%) | Diffuse (90%) | Diffuse (60%) | Diffuse (90%) | Localized, exudative (N=1, 1.9 mm) | Localized, organizing (N=2, 1.8 mm) | Localized, involuted (N=1, 1.6 mm) |
| Maternal age (y) | 25 | 32 | 27 | 28 | 19 | 39 | 36 |
| OB Index* | G1 P0 | G5 P1031 | G4 P0030 | G3 P1011 | G1 P0 | G3 P0020 | G2 P2022 |
| Gestational age (wk) | 27.7 | 37.0 | 32.7 | 29.1 | 38.7 | 40.6 | 35.1 |
| Positive CoV-2 test (predelivery) (d) | 5 | 11 | 7 | 17 | 16 | 1 | 51 |
| COVID-19 symptoms | Mild, recovered | Moderate, recovered | Mild, recovered | Moderate ×7 wk, recovered | Mild, recovered | Mild ×1 wk | Asymptomatic |
| Other maternal | Decreased platelets | Low PAPP-A | Low PAPP-A, preeclampsia | Class 3 obesity | None | Class 2 obesity | Di Di twins, twin B |
| Birth weight (size for GA) | 720 G (AGA) | 3020 G (AGA) | 1750 G (AGA) | 1070 G (AGA) | 2970 G (AGA) | 3400 G (AGA) | 2580 G (AGA) |
| Apgar scores 1/5/10 min | 1/4/9 | 3/7/8 | 2/6/9 | 0/0 (IUFD) | 8/9 | 7/9 | 9/9 |
| Placental weight (size for GA) | 145 G (AGA) | 372 G (AGA) | 269 G (AGA) | 188 G (AGA) | 379 G (AGA) | 505 G (AGA) | 354 G (AGA) |
| Placenta (other) | Fragmented | Accessory lobe | Accessory lobes | Intervillous thrombus | None | Long umbilical cord (82 cm) | Placenta B: Low-grade VUE |
*
Gravidity (total pregnancies); parity (previous full term, preterm, losses before 20 wk, living children).
AGA indicates appropriate for gestational age; Di Di, dichorionic, diamniotic; GA, gestational age; IUFD, intrauterine fetal demise; PAPP-A, pregnancy-associated plasma protein A.