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. Author manuscript; available in PMC: 2022 Jul 14.
Published in final edited form as: Cell Rep. 2022 May 24;39(8):110859. doi: 10.1016/j.celrep.2022.110859

Figure 4. Model for the roles of individual amino acids in E1E2 function.

Figure 4.

Proposed functional model describing the mechanism by which individual amino acids contribute to E1E2 function.

(A) Critical residues for E1 and E2 folding and heterodimerization are shown on simplified representations of the protein structure.

(B) Critical residues for HCV infectivity are assigned to their likely stage in the HCV entry pathway, based on available information of the pathway.