Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 30;12:899622. doi: 10.3389/fonc.2022.899622

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Mohamed, El-Sharkawy, El-Shinawi, Schneider and Mohamed

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Prevalence of HCMV-DNA among IBC patients and IHC staining of IBC cancer tissues against CD14, CD68, CD163, and MAC387. (A) Bars represent prevalence of HCMV IgG among IBC patients. (B) Representative agarose gel electrophoresis showing amplicons of HCMV Immediate Early (IE) gene nested PCR (296 bp) among HCMV⁺ IBC cancer tissues and isolated TME CD14⁺ monocytes. (C) Scatter plot showing the number of metastatic lymph nodes among HCMV^- versus HCMV⁺ IBC patients. (D) Microscopic images of H and E stained paraffin embedded tissue section of HCMV⁺ IBC patients showing invasion of cancer cells to lymphatic vessels. (E, F) Microscopic images of CD14 stained paraffin-embedded tissue sections in HCMV^- versus HCMV⁺ IBC cancer tissues and bars showing a significantly high prevalence of CD14⁺ monocytes among HCMV⁺ compared to HCMV^- IBC cancer tissues. (G, H) Microscopic images of CD14 stained paraffin-embedded tissue sections in HCMV^- versus HCMV⁺ IBC cancer tissues. Bars show no significant difference in the prevalence of CD68⁺ TAMs among HCMV⁺ compared to HCMV^- IBC cancer tissues. (I, J) Microscopic images of CD163 stained paraffin-embedded tissue sections in HCMV^- versus HCMV⁺ IBC cancer tissues. Bars show a significantly high prevalence of CD163⁺ TAMs among HCMV⁺ compared to HCMV^- IBC cancer tissues. (K, L) Microscopic images of MAC387 stained paraffin-embedded tissue sections in HCMV^- versus HCMV⁺ IBC cancer tissues and bars showed a significantly high prevalence of MAC387⁺ TAMs among HCMV⁺ compared to HCMV^- IBC cancer tissues. Data represented the mean of ± SD. P values were calculated using Student t-test, where * represented (P < 0.05).