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. 2022 Jun 30;12:899622. doi: 10.3389/fonc.2022.899622

Figure 5.

Figure 5

Secretome of HCMV+ TAMs enhance the expression of BCSC-related genes in SUM149 cells. (A) Clustered bars represent the mRNA expression of BCSC-related genes in SUM149 cells stimulated by the secretome of HCMV- and HCMV+ TAMs compared to mock cells. Data represent the mean of ± SD (number of experimental replicates = 3). P < 0.05 consider significant as calculated using Student t-test. (B) Gene-gene interaction network of upregulated BCSC-related genes and their neighboring genes. Each node represents a gene, and the size of which represents the strength of the interaction. (C) Bar graph of the top-level Gene Ontology biological processes, colored by P-values. (D) Bar graph of enriched terms across input gene lists, colored by P-values. (E, F) Network of enriched terms: firstly colored by cluster ID, where nodes that share the same cluster ID are typically close to each other; secondly colored by p-value, where terms containing more genes tend to have a more significant P-value. (G, H) Protein-protein interaction network and MCODE components identified in the gene list. (I) Table showed the functional analysis of MCODE1 and MCODE2 components.