Table 1.
Major parameters used in the cost-effectiveness analyses
| Parameters | Value | Range | Reference |
|---|---|---|---|
| Probability of background testing | |||
| Male, among those tested positive | .50 | .20–.50 | Authors’ assumption that only male students with symptomatic infections would get tested, 50% probability of symptomatic infection [22] |
| Female, among those who were sexually active | .44 | .22–.66 | Center for Disease Control and Prevention Medicaid study of 2012 Michigan Medicaid data (personal communication) |
| Female, among those tested positive | .55 | .276–.728 | Authors’ calculation based on 20% probability of symptomatic infection [22], all symptomatically infected females would get tested, 44% of asymptomatically infected females would get tested |
| Test sensitivity | .95 | .9–1 | [17] |
| Treatment efficacy (azithromycin) | .92 | .8–1 | [17] |
| Probability of reinfection | |||
| Male | .11 | .065–.178 | [19] |
| Female | .18 | .09—.27 | [18] |
| Probability of natural clearance | |||
| Male | .20 | .10–.30 | [20] |
| Female | .20 | .10–.30 | [20] |
| Probability of developing epididymitis or PID | |||
| Epididymitis | .02 | .01–.05 | [22] |
| PID | .16 | .12–.30 | .16 (ranging from .12 to .17; [25]), .30 ([24]; [7]), and .15 ([17,22]) |
| Transmission probability per partnership | |||
| Male to female | .70 | .25–.80 | [21] |
| Female to male | .68 | .25–.80 | [21] |
| Clinical screening/testing and treatment costs | |||
| Screening/testing ($) | 57.50 | 28.7–86.2 | [17] |
| Treatment ($) | 29.80 | 14.9–44.7 | [24] |
| Treatment costs of sequelae | |||
| Epididymitis ($) | 1,347 | 673–2,020 | [17] |
| PID ($) | 3,513 | 1,756–5,269 | [26] |
| QALYs lost/case | |||
| Epididymitis | .01 | .0048–.01 | [27] |
| PID | .34 | .177–.53 | [27] |
PID = pelvic inflammatory disease; QALY = quality-adjusted life-years.