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. Author manuscript; available in PMC: 2022 Jul 14.
Published in final edited form as: Arch Pathol Lab Med. 2021 Jun 1;145(6):664–677. doi: 10.5858/arpa.2019-0665-RA

Figure 2.

Figure 2.

Small cell neuroendocrine carcinoma (SCNEC). A and B, SCNEC of the esophagus demonstrating solid sheets of small cells with high N:C ratio, fusiform nuclei, nuclear molding and scant cytoplasm arising in a background of high-grade dysplasia in Barrett esophagus. C, Immunohistochemical staining for synaptophysin shows diffuse staining with focal “dot-like” positivity in some cells. D, Ki-67 immunostaining, with a Ki-67 proliferation index of 90% (hematoxylin-eosin, original magnifications ×2 [A] and ×100 [B]; original magnifications ×200 [C] and ×100 [D]).