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IC50 (μM) and p-values for the HCN4 inhibitors.
| IC50 (μM) | P | ||
|---|---|---|---|
| Ivabradine | HsHCN4 | 37.6 ± 25.6 | 0.958 (Hs4 vs Dr4) |
| DrHCN4 | 30.9 ± 15.3 | 0.674 (Dr4 vs Dr4L) 0.544 (Hs4 vs Dr4L) | |
| DrHCN4L | 10.4 ± 2.6 | ||
| ZD7288 | HsHCN4 | 167 ± 56 | 0.255 (Hs4 vs Dr4) |
| DrHCN4 | 699 ± 216 | 0.950 (Dr4 vs Dr4L) 0.435 (Hs4 vs Dr4L) | |
| DrHCN4L | 596 ± 383 | ||
| Cesium ion | HsHCN4 | 68.8 ± 14.0 | 0.297 (Hs4 vs Dr4) |
| DrHCN4 | 44.3 ± 11.2 | 0.964 (Dr4 vs Dr4L) 0.420 (Hs4 vs Dr4L) | |
| DrHCN4L | 48.3 ± 6.9 |
