TABLE 5.
Inhibitory effects on heart rates (bpm) and p-values in developing zebrafish embryos.
| Heart rate (bpm) | P (vs. control) | ||
|---|---|---|---|
| 0 h (24 hpf) | Control | 87 ± 2 | — |
| Cesium ion (1 mM) | 89 ± 1 | 0.999 | |
| ZD7288 (10 μM) | 81 ± 4 | 0.574 | |
| ZD7288 (100 μM) | 80 ± 3 | 0.357 | |
| ZD7288 (1 mM) | 84 ± 3 | 0.960 | |
| Ivabradine (10 μM) | 81 ± 3 | 0.499 | |
| Ivabradine (100 μM) | 81 ± 2 | 0.589 | |
| Ivabradine (1 mM) | 85 ± 2 | 0.999 | |
| 24 h | Control | 149 ± 4 | — |
| Cesium ion (1 mM) | 131 ± 2 | 0.002 | |
| ZD7288 (10 μM) | 150 ± 3 | 0.999 | |
| ZD7288 (100 μM) | 129 ± 1 | <0.001 | |
| ZD7288 (1 mM) | 113 ± 3 | <0.001 | |
| Ivabradine (10 μM) | 134 ± 4 | 0.021 | |
| Ivabradine (100 μM) | 124 ± 5 | <0.001 | |
| Ivabradine (1 mM) | 98 ± 2 | <0.001 | |
| 48 h | Control | 174 ± 5 | — |
| Cesium ion | 133 ± 2 | <0.001 | |
| ZD7288 (10 μM) | 142 ± 2 | <0.001 | |
| ZD7288 (100 μM) | 97 ± 4 | <0.001 | |
| ZD7288 (1 mM) | 94 ± 2 | <0.001 | |
| Ivabradine (10 μM) | 133 ± 2 | < 0.001 | |
| Ivabradine (100 μM) | 101 ± 2 | <0.001 | |
| Ivabradine (1 mM) | 72 ± 2 | <0.001 | |
| Heart rate (bpm) | P (vs. 48 h) | ||
| Washout | Control | 165 ± 3 | — |
| Cesium ion | 139 ± 3 | 0.168 | |
| ZD7288 (10 μM) | 160 ± 3 | <0.001 | |
| ZD7288 (100 μM) | 140 ± 4 | <0.001 | |
| ZD7288 (1 mM) | 115 ± 2 | <0.001 | |
| Ivabradine (10 μM) | 149 ± 3 | 0.002 | |
| Ivabradine (100 μM) | 133 ± 3 | <0.001 | |
| Ivabradine (1 mM) | 115 ± 3 | <0.001 |