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. 2022 Jul 13;2022(7):CD012269. doi: 10.1002/14651858.CD012269.pub2

CAVAD.

Methods Randomised, blinded trial 
Participants Inclusion criteria
  1. Age range 40–80 years

  2. After newly ischemic stroke from 3 months to 2 years

  3. Brain CT or MRI shows stroke lesions and white matter lesions, ARWMC ≥ 4

  4. Moderate or mild cognitive deficits: MMSE 12–26

  5. Vascular or mixed dementia: Hachinski ischaemic score > 4

  6. Moderate or mild disability: mRS ≤ 4, NIHSS < 20

  7. Informed consent


Exclusion criteria
  1. Definitive diagnosis of dementia prior to the stroke

  2. Cerebral haemorrhage in the past

  3. Cerebral embolism resulting from cardiogenic embolus

  4. Critically ill: mRS > 4, NIHSS ≥ 20

  5. Immobile person with undiagnosed new stroke

  6. Severe cardiac, hepatic or nephric complication

  7. Dementia not caused by vascular lesions

  8. Other diseases disturbing cognitive evaluation

  9. Susceptibility to varieties of allergen

  10. Contraindication to cilostazol or aspirin

  11. Antiplatelet treatment, anticoagulation or fibrinolysis needed for other diseases

  12. Rejected from participation by the patient or the family

Interventions Cilostazol 100 mg twice daily for 12 months
Aspirin 100 mg once daily for 12 months
Outcomes Primary outcomes: changes in cognitive scores (MMSE, Montreal Cognitive Assessment, Clinical Dementia Rating and Blessed‐Roth (time frame 1 year) 
Notes Requested further information but no response from trial team.

CT: computed tomography; MMSE: Mini‐Mental State Examination; MRI: magnetic resonance imaging; mRS: Modified Rankin Score; NIHSS: National Institutes of Health Stroke Scale.