Figure 1.

Management of anticoagulation in cancer patients with TP. *Stable grade 1–2 TP is defined as platelet counts, which are not expected to decrease to grade 3–4 TP in the coming days to weeks. †AF with arterial thromboembolism in the past 3 mo; AF with CHA2DS2-VASc ≥ 6; VTE in past 3 mo; mechanical heart valves where full-dose anticoagulation was not possible. ‡Stable grade 3 TP defined as platelet counts, which are not expected to decrease to grade 4 TP in the coming days to weeks. §VTE within the past 30 d. ¶Only in case of lower extremity DVT or pulmonary embolism. **This strategy can be used for a maximum of 14 d. AF = atrial fibrillation; DVT = deep vein thrombosis; INR = international normalized ratio; LAAO = left atrial appendage occlusion; LMWH = low-molecular weight heparin; TP = thrombocytopenia; Tx = transfusion; VKA = vitamin K antagonist; VTE = venous thromboembolism.