Table 1.
Clinical characteristics of the seizure group in therapeutic hypothermia (TH)-treated HIE newborns (n = 97).
| No clinical seizure (n = 19) | Clinical seizure (n = 78) | P | |
| Gestational age, wks | 40 (39.07∼40.14) | 39.64 (38.29∼40.14) | .512 |
| Birth weight, g | 3260 (3155∼3560) | 3175 (2942.5∼3437.5) | .100 |
| Maternal age, yr | 32.42 (2.67) | 32.5 (4.75) | .945 |
| Apgar score at 1 min | 1 (15 (78.9)) | 53 (67.9) | .429 |
| Apgar score at 5 min | 2 (3 (15.8)) | 20 (25.6) | .430 |
| Outborn, n (%) | 3 (15.8) | 23 (29.5) | .358 |
| Male, n (%) | 4 (21.1) | 36 (46.2) | .083 |
| MAS, n (%) | 2 (10.5) | 6 (7.7) | 1.000 |
| SGA, n (%) | 1 (5.3) | 7 (9) | .950 |
| Fetal heart deceleration | 14 (73.7) | 61 (78.2) | .907 |
| Emergent csearean section | 14 (73.7) | 69 (88.5) | .201 |
| Initial serum pH < 7.0 | 19 (100) | 78 (100) | 1.000 |
| Initial BE | 8.37 (4.81) | 6.95 (4.58) | .231 |
| LDH (initial) | 1234.53 (392) | 1232.94 (525.7) | .990 |
| CPK (initial) | 1122.16 (819.82) | 903.38 (838.3) | .309 |
| Abnormal aEEG | .008 | ||
| Mild abnormal | 1 (5.3) | 6 (7.7) | |
| Moderate abnormal | 6 (31.6) | 50 (64.1) | |
| Severe abnormal | 0 (0) | 4 (5.1) | |
| AED, Phenobarbital | 12 (63.2) | 77 (98.7) | <.001 |
| AED, keppra | 0 (0) | 37 (47.4) | <.001 |
| AED, phenytoin | 0 (0) | 10 (12.8) | .220 |
| Ventilator care, d | 2.63 (2.14) | 3.53 (2.93) | .212 |
| Full feeding days | 6.79 (1.62) | 8.04 (3.4) | .123 |
| Hospital days | 10.89 (2) | 13.26 (4.44) | .026 |
| PPHN (%) | 2 (10.5) | 4 (5.1) | .730 |
| AEP refer | 3 (15.8) | 9 (11.7) | .628 |
| Expired = 0 (%) | 19 (100) | 78 (100) | 1.000 |
AED = antiepileptic drug, aEEG = amplitude-integrated electroencephalogram, AEP = auditory evoked potential, BE = base excess, CPK = creatine phosphokinase, HIE = hypoxic ischemic encephalopathy, LDH = lactate dehydrogenase, MAS = meconium aspiration syndrome, MRI = magnetic resonance imaging, NSD = normal spontaneous delivery, PPHN = persistent pulmonary hypertension, SGA = small for gestational age.