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. 2022 Jul 14;12:12047. doi: 10.1038/s41598-022-16357-2

Table 2.

Events, person-years of observation, and crude incidence rates per 1000 person-years [with 95% exact Poisson confidence intervals (CI)] for various COVID-19 outcomes in the three studied cohorts (overall population cohort, COVID-19 onset cohort and hospitalized cohort), by statin use.

Cohort COVID-19 outcomes Statin users Non-users P value
Events Person-years Incidence rates [95% CI] Events Person-years Incidence rates [95% CI]
Overall cohort N = 127,542 N = 445,153
Test-positive 5822 128,885 45.2 [44.0–46.3] 25,376 450,753 56.3 [55.6–57.0]  < 0.001
Diagnosis 6389 128,667 49.7 [48.4–50.9] 26,633 450,297 59.1 [58.4–59.9]  < 0.001
Hospitalization 2902 129,684 22.4 [21.6–23.2] 6238 454,928 13.7 [13.4–14.1]  < 0.001
ICU admission 166 130,037 1.30 [1.10–1.50] 264 455,684 0.60 [0.50–0.70]  < 0.001
Death 1042 130,084 8.0 [7.50–8.50] 2722 455,782 6.0 [5.70–6.20]  < 0.001
Onset cohort N = 52,128 N = 242,785
Hospitalization 15,227 8521 1787.1 [1758.8–1815.7] 24,857 46,129 538.9 [532.2–545.6]  < 0.001
ICU admission 1543 13,627 113.2 [107.7–119] 2701 54,901 49.2 [47.4–51.1]  < 0.001
Death 4208 12,596 334.1 [324.0–344.3] 6282 53,522 117.4 [114.5–120.3]  < 0.001
Hospitalized cohort N = 15,246 N = 24,846
ICU admission 1522 5196 292.9 [278.4–308] 2673 8910 300 [288.7–311.6]  < 0.001
Death 2884 4735 609.1 [587.1–631.8] 3386 8788 385.3 [372.4–398.5]  < 0.001