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. 2022 Jul 8;119(28):e2206113119. doi: 10.1073/pnas.2206113119

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Copyright © 2022 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).

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Fig. 4. — The effects of TDI-011536 treatment on gene expression. (A) Principal-components analysis of gene expression in the liver and heart indicates that the data are separated first on the basis of the respective organs, then in response to treatment with TDI-011536. The first principal component (PC1) captures 87.5% of the explained variance and the second (PC2) accounts for 3.8%. (B) A volcano plot demonstrates up-regulation of Yap target genes after exposure to TDI-011536 in the liver. Examples of well-characterized targets of Yap are indicated as hollow circles: angiomotin-like 2 (Amotl2), cellular communication network factor 1 (Ccn1), cellular communication network factor 2 (Ccn2), and myc proto-oncogene (Myc) The dashed horizontal line represents an adjusted probability level of P_adj = 0.05. (C) The corresponding volcano plot for the heart reveals a similarly robust enhancement of expression of Yap target genes. Data relating to gene expression in response to TDI-011536 treatment are available at GEO (https://www.ncbi.nlm.nih.gov/geo/query/acccgi?acc=GSE196322).