Figure 2.

Importance of each feature to the predictive model for all 32 features where brown indicates above the 50% threshold (16 features). Of the 16 features there were 5 nonmetabolite features (islet autoantibody [IAAb] at age 9 months, DR3/4, genetic risk score [GRS], gestational age, and exposure to cow’s milk before age 6 months), 3 metabolites measured at age 3 months, 5 metabolites measured at age 6 months, and 3 metabolites measured at age 9 months. Inset is the area under the curve (AUC) value achieved by feature reduction using ROFI-based thresholds where the x-axis on the left indicates the Repeated Optimization for Feature Interpretation (ROFI) feature importance score and the y-axis on the right indicates the average AUC of the model based on the threshold. The ROFI-based threshold of 50%, brown square, is a common threshold in this is case also relates to a near optimal AUC.