Table 1.
Reproductive parameters of the discovery cohort, oligozoospermic subgroup, and validation cohort
| Discovery cohort (n = 742) | Oligozoospermic subgroup of discovery cohort (n = 294) | Validation cohort (n = 1123) | |
|---|---|---|---|
| Age, y | 36 ± 5.7 | 35.9 ± 5.7 | 35 ± 6.2 |
| 35 (28-46) | 35 (28-46) | 35 (26-45) | |
| FSH, IU/L (1-7] | 5.3 ± 3.9 | 7.3 ± 4.8 | 5.4 ± 4.5 |
| 4.2 (1.7-13.2) | 5.9 (2.3-16.1) | 4.2 (1.7-13.1) | |
| n FSH 1-7 IU/L, % | 79, 40% | 61, 90% | 79, 30% |
| n FSH > 7 IU/L, % | 20, 60% | 38, 10% | 20, 70% |
| LH, IU/L (2-10) | 3.3 ± 1.7 | 4 ± 2 | 3.6 ± 2 |
| 2.9 (1.4-6.6) | 3.7 (1.6-7.5) | 3.2 (1.5-6.8) | |
| FSH/LH | 1.7 ± 0.9 | 1.9 ± 1 | 1.6 ± 1.1 |
| 1.5 (0.6-3.4) | 1.8 (0.7-3.9) | 1.4 (0.5-3.3) | |
| Testosterone, nmol/L (≥ 12) | 17.1 ± 6.1 | 17.2 ± 6.4 | 16.4 ± 6.4 |
| 16.4 (9.2-28.5) | 16.1 (9-28.2) | 15.3 (9.1-27.3) | |
| Bitestic. volume, mL | 39.6 ± 14.2 | 34.6 ± 12.1 | 41.2 ± 14 |
| 37 (21.1-63) | 33 (20-58) | 40 (21-67) | |
| Ejaculate volume, mL | 4 ± 1.7 | 3.7 ± 1.6 | 3.9 ± 1.6 |
| 3.7 (1.8-7) | 3.5 (1.7-6.6) | 3.5 (1.8-7) | |
| Total sperm count, Mill/ejac | 106.3 ± 135.1 | 14.5 ± 11.1 | 109.5 ± 158.9 |
| 58.7 (2.1-380.9) | 11.8 (1.3-35) | 57.2 (2.1-370.7) | |
| n ≥ 39 Mill/ejac, % | 60,40% | 0,00% | 57,30% |
| n < 39 Mill/ejac, % | 39,60% | 100,00% | 42,70% |
| Sperm conc, Mill/mL | 28.4 ± 34.4 | 4.6 ± 4.3 | 30.1 ± 41.5 |
| 16.4 (0.6-104.4) | 3.5 (0.4-12.7) | 16.4 (0.6-104.7) | |
| Sperm ab-motility, % | 43.8 ± 12.4 | 37.1 ± 13.6 | 43.2 ± 13.2 |
| 46 (18.9-58.1) | 38 (14-55) | 46 (17-58) | |
| Sperm morphology | 3.8 ± 2 | 2.9 ± 1.6 | 4.5 ± 2.6 |
| 4 (1-7) | 3 (1-6) | 4 (1-9) |
Data are presented as mean ± SD and median (5th-95th percentile). Reference range of hormones is indicated in parentheses.
Abbreviations: Bitestic, bitesticular; ejac, ejaculation; FSH, follicle-stimulating hormone; LH, luteinizing hormone.