Figure 5.

Representative luteinizing hormone (LH) pulse profiles from participant subsets. A, This section shows results from a representative individual (participant 4) from subset with progesterone levels suggestive of anovulatory state (n = 6), with a suppressed hypothalamic-pituitary-gonadal (HPG) axis at visit 1, showing dampened LH pulsatility and hypogonadal state expected in the context of high prolactin levels; B, This section shows results from a representative individual (participant 8) from a subset with progesterone levels suggestive of ovulatory state (n = 3), with an HPG axis that was not fully suppressed. The shaded region represents the time frame of kisspeptin administration. Dashed lines represent kisspeptin bolus administration. Inverted triangles represent pulses as defined by modified Santen and Bardin method.