Figure 1.

Study design (A) and CONSORT flow diagram (B). Abbreviations: AL, ad libitum; FMD, fasting-mimicking diet; M-Diet, Mediterranean diet; rV3, visit at refeeding 1 week after the third diet cycle; rV6, visit at refeeding one week after the sixth diet cycle; V0, visit at baseline; V1, visit after the first diet cycle; V2, visit after the second diet cycle; V3, visit after the third diet cycle; V4, visit after the fourth diet cycle; V5, visit after the fifth diet cycle; V6, visit after the sixth diet cycle; V7, follow-up visit 3 months after study completion.