Table X.

Summary of Toxicity Profile of NPS Opioids

Organ system	Symptoms and signs
CNS	Analgesia, somnolence and sedation
Cardiovascular	Hypercarbia, acidosis and hypoxemia
Pulmonary	Hypoventilation that can progress to respiratory arrest
Other	Miosis; constipation; rapid onset of rigidity of muscles in the jaw, neck, chest wall and abdomen
Postmortem findings	Organ edema and congestion; urine retention; frothy watery fluid in airways