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. 2022 Apr 21;46(6):e116–e185. doi: 10.1093/jat/bkac023

Table VI.

Summary of Toxicity Profile of NPS Hallucinogen Drug Subclasses

Organ system PCP-like analogues Ketamine analogues Phenethylamine analogues
CNS Delusions, confusion, aggression, psychomotor agitation, altered or fluctuating consciousness Agitation, aggression, abnormal behavior, hallucination, delusions, impaired consciousness, loss of consciousness, unstable emotions, psychotic symptoms and unsteady gait Agitation, aggression, seizures, euphoria, hallucinations and loss of consciousness
Cardiovascular Tachycardia and hypertension Tachycardia, hypertension and palpitations Tachycardia, hypertension and cardiac arrest
Pulmonary Tachypnea, respiratory acidosis Dyspnea Respiratory distress, heavy breathing and apnea
Other Hypothermia, mydriasis, excessive sweating and vertical nystagmus Hyperthermia, rhabdomyolysis, nystagmus, drowsiness, dizziness, convulsion, nausea, vomiting and self-harm Hyperthermia, mydriasis, rhabdomyolysis, sweating, salivation, tremors and serotonin syndrome
Postmortem findings Edema and congestion of lungs, brain and heart Brain swelling and lung hyperhydration Edema and congestion of lungs and brain