Table 3.

Steroid hormone concentrations in women predicts morphological features of adipose tissue dysfunction

		Unadjusted model					Adjusted model
Independent variable	Dependent variable	Beta	SE	P value	Adjusted R2	AIC	Beta	SE	P value	Adjusted R2	AIC
Plasma cortisone	SAT adipocyte cell diameter	0.31	0.11	0.01	0.20	202.30	0.31	0.11	0.009	0.29	201.52
SAT cortisone	SAT pericellular fibrosis	4.0 E -05	1.2 E -05	0.002	0.34	79.34	4.1 E -05	1.3 E -05	0.005	0.24	84.98
SAT estradiol	SAT pericellular fibrosis	4.9 E -04	1.1 E -05	0.0002	0.44	88.86	5.6 E -04	1.4E -04	0.0006	0.42	92.41
SAT estrone	SAT pericellular fibrosis	2.5 E -04	7.9 E -05	0.001	0.31	100.37	2.7 E -04	7.8 E -05	0.002	0.29	103.37
VAT E1: A4	VAT adipocyte diameter	84.97	32.38	0.01	0.19	210.67	89.80	32.12	0.01	0.35	207.10
VAT E1: A4	HDL-c	-1.86	0.71	0.01	0.16	14.84	-1.94	0.64	0.005	0.44	5.10
SAT E1: A4	Triglycerides	3.95	1.3	0.005	0.21	62.66	3.54	1.46	0.02	0.16	67.29
SAT E1: A4	HDL-c	-2.06	0.54	0.0006	0.31	8.29	-1.53	0.55	0.009	0.40	6.25

Cortisone and intra-adipose estrogen are associated with adipocyte cell size and pericellular fibrosis. Intra-adipose estrone: androstenedione (E1:A4) ratio in women predicts features of adipose tissue dysfunction. Adjusted model takes into consideration waist circumference, age, and anovulant drug use.

Abbreviations: AIC, Akaike information criterion; HDL-c, high-density lipoprotein cholesterol; SAT, subcutaneous adipose tissue; SE, standard error; VAT, visceral adipose tissue.