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. 2022 Jul 8;119(28):e2122301119. doi: 10.1073/pnas.2122301119

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Copyright © 2022 the Author(s). Published by PNAS.

This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 3. — Evolution of NETO and related proteins. A dendrogram from a RAxML analysis with bootstrap values ≥50% shown. Species abbreviations for species not defined in the Fig. 1 legend: Am, Apis melifera; Cg, Crassostrea (Magallana) gigas; Ct, Capitella teleta; La, Lingula anatina; Sk, Saccoglossus kowalevskii; Sp, Strongylocentrotus purpuratus. The outgroup was Capsaspora owczarzaki cubilin (not shown). Vertebrate genes are colored in red shades, ambulacrarian genes are in purple shades, ecdysozoan genes are in orange shades, molluscan genes are in blue shades, and nonmolluscan spiralian genes are in green shades. We identified a new protostome-only branch of the family, NETO-Pro. LEV-10 (identified in a screen for resistance to the cholinergic agonist levamisole) and suppressor of lurcher (SOL) were named after the founding C. elegans proteins. SOL2 in C. elegans is a member of the NETOpro family. Note that the NETOx group of genes is specific for early-branching deuterostomes.