Fig. 6.

Antibody and lectin α-gal binding modes. The M86 structure (orange Ig domains and blue galactobiose) superposed about the central GAL moiety with (A) galectin CGL2 from Coprinopsis cinerea (teal cartoon and ligand, PDB entry 1ule), and (B) lectin MOA from Marasmius Oreades (pink cartoon and ligand, PDB entry 2iho). Both employ a shallow elongated cleft and employ a tryptophan (W72 and W35, respectively) analogous to W33 in the M86 structure, adjacent to the α-face of the penultimate GAL unit. Perspectives from above (Top) and the side (Bottom) are shown.