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. 2022 Jul 14;17(7):e0269875. doi: 10.1371/journal.pone.0269875

Table 3. Predictive models for worsening during the first week among mild patients at admission.

A) B (SE) Wald p OR (95% CI)
SpO2 <93% 1.46 (0.45) 10.15 <0.001 4.32 (1.75–10.62)
Sex (male) -1.33(0.60) 4.90 0.027 3.84 (1.17–12.5)
No oral corticosteroids -1.05 (0.46) 4.73 0.030 2.77 (1.11–7.14)
CRP >67 mg/L 1.87 (0.48) 15.07 <0.001 6.54 (2.53–16.88)
NLR ≥5.86 1.96 (0.56) 12.28 <0.001 7.15 (2.38–21.49)
Monocytes <0.315 x 109/L 1.69 (0.49) 11.84 0.001 5.42 (2.07–14.22)
B)
SpO2 <93% 1.87 (0.56) 10.92 0.001 6.49 (2.14–19.69)
Sex (male) 1.43 (0.67) 4.53 0.033 4.34 (1.12–16.66)
CRP >67 mg/L 1.23 (0.55) 4.94 0.026 3.44 (1.15–10.22)
NLR ≥5.86 1.84 (0.64) 8.15 0.004 6.31 (1.78–22.40)
Monocytes <0.315 x 109/L 1.93 (0.60) 10.18 0.001 6.94 (2.11–22.85)
IL-8 >9.98 pg/mL 2.18 (0.91) 5.73 0.017 8.88 (1.48–53.13)
MIP-1β >20.4 pg/mL 1.34 (0.64) 4.44 0.037 3.83 (1.08–13.58)
sCD25 >2080 pg/mL 1.36 (0.65) 4.36 0.037 3.91 (1.08–14.08)

A) Model carried out only with clinical parameters and routine laboratory parameters, Nagelkerke R2, 0.482. Hosmer-Lemeshow χ2, 10.25, p = 0.247. B) Model carried out with clinical parameters, routine laboratory parameters and pro-inflammatory cytokines. Nagelkerke R2, 0.625. Hosmer-Lemeshow χ2 3.62, df 8; p = 0.889. B, beta coefficient; SE, standard error; OR, odds ratio; SpO2, peripheral capillary oxygen saturation; CRP, C-reactive protein; NLR, neutrophil/lymphocyte ratio; IL-8, interleukine-8; MIP-1β, macrophage inflammatory proteins 1β; sCD25, interleukine-2 soluble receptor.