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. 2022 Jul 14;18(7):e1010649. doi: 10.1371/journal.ppat.1010649

Fig 5. Acute phase blood biomarkers in C57BL/6 versus CC057 mice.

Fig 5

A) CBC and B) CHEM over time with data presented as a function of difference from the uninfected mean, shown as mean ± SD (n = 3–7 mice/time point). Each data point shown represents an individual mouse. The uninfected means and normal ranges for C57BL/6 and CC057 mice were determined by performing CBC and CHEM on blood from 9 uninfected C57BL/6 mice and 9 uninfected CC057 mice. Uninfected normal ranges from the mean for C57BL/6 and CC057 mice are represented by grey and pink horizontal shading respectively. Comparisons of CBC data were performed at each timepoint by Mann-Whitney to compare RVFV-infected samples to uninfected control samples for each mouse strain separately (C57BL/6: Total white blood cells 3 dpi p = 0.0164; Lymphocytes 3 dpi p = 0.0164; Platelets 1 dpi p = 0.0091. CC057: Neutrophils 3 dpi p = 0.0098; Hemoglobin 0.5 dpi p = 0.0182, 3 dpi p = 0.0499). Comparisons of CHEM data were performed at each timepoint by Mann-Whitney to compare RVFV-infected samples to uninfected control samples for each mouse strain separately (C57BL/6: ALT 3 dpi p = 0.0298; ALP 3 dpi p = 0.0052). C) Analyte levels in the plasma at 3 dpi. Data shown as the mean (C57BL/6 n = 15; CC057 n = 3).