Skip to main content
. 2022 Jul 14;18(7):e1010649. doi: 10.1371/journal.ppat.1010649

Fig 7. Cytokine signaling and markers of endothelial activation in RVFV-infected CC057 mice.

Fig 7

Analyte concentrations in the plasma over time with data presented as a function of difference from the uninfected mean, shown as mean ± SD (n = 3 mice/time point). Each data point shown represents an individual mouse. Pink horizontal shading represents uninfected normal ranges from the mean for CC057 mice. For each analyte, comparisons were performed at each timepoint by Mann-Whitney to compare RVFV-infected samples to uninfected control samples. A) Cytokines and chemokines: IL-10 (7 dpi p = 0.0061); IP-10 (5 dpi p = 0.0121; 7 dpi p = 0.0121); IL-6 (7 dpi p = 0.0121); MIG (5 dpi p = 0.0121; 7 dpi p = 0.0121); MCP-1 (7 dpi p = 0.0182). B) Tissue barriers: ICAM (5 dpi p = 0.0424); PAI-1 (5 dpi p = 0.0121; 9 dpi p = 0.0242); MMP-9 9 dpi (p = 0.0121); Thrombomodulin (5 dpi p = 0.0121; 7 dpi p = 0.0121; 9 dpi p = 0.0242).