Table 2. Inhibition Properties of Benzoxaborole 12 against Various PBP variantsa.
| protein tested | residual activity by BOCILLIN FL FA (%) |
|---|---|
| PBP3 from P. aeruginosa | 16 ± 6 |
| PBP3 from H. Influenzae | 32 ± 3 |
| PBP3 from A. baumannii | 73 ± 3 |
| PBP3 from E. coli | >90 |
| PBP2 from N. gonorrhoeae | >90 |
a
Residual activities (treatment with 12 (1 mM) for 1 h, the activity determined by BOCILLIN FL competition assay) are given as a percentage of the untreated control, with errors as standard deviations of three technical replicates. Note that the N. gonorrhoeae PBP2 was a transpeptidase-only construct.