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. 2022 Jul 14;17(7):e0271327. doi: 10.1371/journal.pone.0271327

Table 2. Clinical diagnostic, sensory symptoms, neuropathy profile, and test site of the patients.

Patient Age Sex Pain duration (years) Neuropathy Detailed diagnosis Painful site Sensory symptoms on painful site Sensory profile Examinated painful site Examinated painless site Analgesia lidocaine patch
1 73 M 1 Polyneuropathy Idiopathic PNP Both lower legs and feet Hypoaesthesia to cold
Pinprick hyperalgesia
Thermal loss
Mechanical gain
Dorsum foot L Ventral forearm L No
2 77 F 1 Polyneuropathy Chemical induced PNP Both feet and hands Hypoaesthesia to cold
Hypoaesthesia to touch Pinprick hyperalgesia
Thermal loss
Mechanical loss
Mechanical gain
Dorsum foot L Ventral forearm L Yes
3 57 F n/a Mononeuropathy Lesion fibularis nerve Foot R Hyperaesthesia to cold
Pinprick hyperalgesia
Thermal gain
Mechanical gain
Dorsum foot R Dorsum foot L No
4 31 F 2 Mononeuropathy Lesion fibularis nerve Foot R Hyperaesthesia to cold
Pinprick hyperalgesia
Thermal gain
Mechanical gain
Dorsum foot R Dorsum foot L Yes
5 65 F 1 Mononeuropathy Lesion fibularis nerve Lower leg and foot R Hypoaesthesia to cold
Hypoaesthesia to touch
Thermal loss
Mechanical loss
Dorsum foot R Dorsum foot L n/a
6 80 M n/a Polyneuropathy Idiopathic PNP Both feet and hands Hyperaesthesia to cold
Hypoaesthesia to touch
Thermal gain
Mechanical loss
Dorsum hand L Ventral forearm L No
7 52 M n/a Polyneuropathy Idiopathic PNP Both feet n/a n/a Dorsum foot L Ventral forearm L n/a
8 55 F 3 Polyneuropathy Chemical induced PNP Both feet Anaesthesia to temperature Thermal loss Dorsum foot L Ventral forearm L No
9 55 M 2.5 Polyneuropathy Diabetic PNP Both legs and feet Hyperaesthesia to cold
Hypoaesthesia to touch
Pinprick hyperalgesia
Thermal gain
Mechanical loss
Mechanical gain
Ventral upper leg L Ventral forearm L No
10 62 F 2 Mononeuropathy Lesion plantar nerve Foot R Allodynia to touch
Pinprick hyperalgesia
Mechanical gain Plantar foot R Plantar foot L Yes
11 77 F 4 Polyneuropathy Chemical induced PNP Both feet and hands Allodynia to touch Mechanical gain Dorsum foot R Upper arm R No
12 70 F n/a Polyneuropathy Chemical induced PNP Both feet Pinprick hyperalgesia Mechanical gain Dorsum foot R Ventral forearm R n/a
13 72 F n/a Polyneuropathy Diabetic PNP Both feet Hypoaesthesia to cold Thermal loss Dorsum foot R Ventral forearm R n/a
14 49 M 22 Mononeuropathy Lesion peroneal nerve Lateral lower leg and dorsal foot L Hypoaesthesia to cold
Hypoaesthesia to touch
Pinprick hypoalgesia
Thermal loss
Mechanical loss
Dorsum foot L Dorsum foot R n/a
15 63 M 11 Polyneuropathy Guillain-Barré syndrome Both feed, hand R Hypoaesthesia to cold
Hypoaesthesia to touch
Pinprick hypoalgesia
Thermal loss
Mechanical loss
Dorsum foot L Ventral upper leg L No
16 51 M 4 Radiculopathy Root L5 Both feet Hypoaesthesia to cold
Hypoaesthesia to touch
Pinprick hypoalgesia
Thermal loss
Mechanical loss
Dorsum foot L Dorsal hand L No
17 57 M 13 Polyneuropathy Idiopathic SFN Both feed Hypoaesthesia to touch
Pinprick hyperalgesia
Mechanical loss
Mechanical gain
Dorsum foot L Upper arm L No
18 42 F 1.5 Polyneuropathy Inflammatory SFN Both legs Hypoaesthesia to cold
Hypoaesthesia to touch
Pinprick hyperalgesia
Thermal loss
Mechanical loss
Mechanical gain
Dorsum foot R Dorsal forearm R No
19 38 F 3 Mononeuropathy Lesion peroneal nerve Lower leg and foot L Hyperesthesia to cold
Hypoaesthesia to touch
Pinprick hyperalgesia
Thermal gain
Mechanical loss
Mechanical gain
Dorsum foot L Ventral upper leg L No
20 57 m 6 Polyneuropathy Idiopathic PNP 1st to 3rd toes bilateral Hypoaesthesia to cold
Dysaesthesia to touch
Pinprick hypoalgesia
Thermal loss
Mechanical gain
Mechanical loss
1st toe R Lower leg R No
21 55 F 8 Polyneuropathy Guillain-Barré syndrome Both lower legs and feet Anaesthesia to cold
Dysaesthesia to touch
Pinprick hypoalgesia
Thermal loss
Mechanical gain
Mechanical loss
Dorsum foot R Ventral upper leg R Yes
22 56 M 0.5 Polyneuropathy Guillain-Barré syndrome Foot L Hypoaesthesia to cold
Allodynia to touch
Pinprick hypoalgesia
Thermal loss
Mechanical gain
Mechanical loss
Dorsum foot L Shoulder L Yes
23 64 M 0.5 Mononeuropathy Lesion radial nerve Radial nerve distribution hand R Hypoaesthesia to cold
Dysaesthesia to touch
Pinprick hypoalgesia
Thermal loss
Mechanical gain
Mechanical loss
Radial nerve distribution hand R Dorsal forearm L Yes
24 63 M 2 Polyneuropathy Diabetic SFN All toes bilateral Hypoaesthesia to cold
Dysaesthesia to touch
Pinprick hypoalgesia
Thermal loss
Mechanical gain
Mechanical loss
1st toe L Upper arm L No
25 53 F 4 Mononeuropathy Lesion saphenous nerve Saphenous nerve distribution R Hypoaesthesia to cold
Allodynia to touch Pinprick hyperalgesia
Thermal loss
Mechanical gain
Medial lower leg R Medial lower leg L No
26 51 M 32 Plexopathy arm plexus lesion lower part Ulnar nerve distribution L Anaesthesia to cold
Allodynia to touch
Pinprick hyperalgesia
Thermal loss
Mechanical gain
4th finger dorsal L 4th finger dorsal L No
27 63 F 6 Radiculopathy Root L5 L5 dermatome lower leg L Hypoaesthesia to cold
Dysaesthesia to touch
Pinprick hyperalgesia
Thermal loss
Mechanical gain
Ventro-lateral lower leg L Ventral upper leg L No
28 61 F 12 Polyneuropathy Idiopathic SFN Both feet Hypoaesthesia to cold
Allodynia to touch
Pinprick hyperalgesia
Thermal loss
Mechanical gain
Dorsum foot R Ventral upper leg R Yes
29 61 M 4 Radiculopathy Root L5 L5 dermatome R Hypoaesthesia to cold
Dysaesthesia to touch
Pinprick hyperalgesia
Thermal loss
Mechanical gain
Dorsum foot R Dorsum foot L No
30 42 M 0.5 Radiculopathy Root L4 Ventro-medial lower leg R Hypoaesthesia to cold
Allodynia to touch
Pinprick hyperalgesia
Thermal loss
Mechanical gain
Ventro-medial lower leg R Radial forearm R No
31 23 M 2 Polyneuropathy Idiopathic SFN Both feet Dysaesthesia to touch
Pinprick hyperalgesia
Mechanical gain Dorsum foot R Ventral upper leg R No
32 61 M 6 Mononeuropathy Lesion ulnar nerve Ulnar nerve distribution L Allodynia to touch
Pinprick hyperalgesia
Mechanical gain Dorsal ulnar hand L Dorsal ulnar hand R Yes
33 48 M 5 Radiculopathy Root L5 1st toe L Dysaesthesia to touch
Pinprick hyperalgesia
Mechanical gain 1st toe L Ventral upper leg L No

Patients’ etiology of neuropathy, sensory profile, test areas of affected (neuropathic/painful) and non-affected (control) skin sites, and presence of lidocaine 5% patch analgesia defined as reduction of acute (spontaneous) pain at visit by NRS values exceeding 1. Note that 5 patients did not return the questionnaire and in 1 patient the sensory profile was not assessed (n/a).