Table 2. Clinical diagnostic, sensory symptoms, neuropathy profile, and test site of the patients.
Patient | Age | Sex | Pain duration (years) | Neuropathy | Detailed diagnosis | Painful site | Sensory symptoms on painful site | Sensory profile | Examinated painful site | Examinated painless site | Analgesia lidocaine patch |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 73 | M | 1 | Polyneuropathy | Idiopathic PNP | Both lower legs and feet | Hypoaesthesia to cold Pinprick hyperalgesia |
Thermal loss Mechanical gain |
Dorsum foot L | Ventral forearm L | No |
2 | 77 | F | 1 | Polyneuropathy | Chemical induced PNP | Both feet and hands | Hypoaesthesia to cold Hypoaesthesia to touch Pinprick hyperalgesia |
Thermal loss Mechanical loss Mechanical gain |
Dorsum foot L | Ventral forearm L | Yes |
3 | 57 | F | n/a | Mononeuropathy | Lesion fibularis nerve | Foot R | Hyperaesthesia to cold Pinprick hyperalgesia |
Thermal gain Mechanical gain |
Dorsum foot R | Dorsum foot L | No |
4 | 31 | F | 2 | Mononeuropathy | Lesion fibularis nerve | Foot R | Hyperaesthesia to cold Pinprick hyperalgesia |
Thermal gain Mechanical gain |
Dorsum foot R | Dorsum foot L | Yes |
5 | 65 | F | 1 | Mononeuropathy | Lesion fibularis nerve | Lower leg and foot R | Hypoaesthesia to cold Hypoaesthesia to touch |
Thermal loss Mechanical loss |
Dorsum foot R | Dorsum foot L | n/a |
6 | 80 | M | n/a | Polyneuropathy | Idiopathic PNP | Both feet and hands | Hyperaesthesia to cold Hypoaesthesia to touch |
Thermal gain Mechanical loss |
Dorsum hand L | Ventral forearm L | No |
7 | 52 | M | n/a | Polyneuropathy | Idiopathic PNP | Both feet | n/a | n/a | Dorsum foot L | Ventral forearm L | n/a |
8 | 55 | F | 3 | Polyneuropathy | Chemical induced PNP | Both feet | Anaesthesia to temperature | Thermal loss | Dorsum foot L | Ventral forearm L | No |
9 | 55 | M | 2.5 | Polyneuropathy | Diabetic PNP | Both legs and feet | Hyperaesthesia to cold Hypoaesthesia to touch Pinprick hyperalgesia |
Thermal gain Mechanical loss Mechanical gain |
Ventral upper leg L | Ventral forearm L | No |
10 | 62 | F | 2 | Mononeuropathy | Lesion plantar nerve | Foot R | Allodynia to touch Pinprick hyperalgesia |
Mechanical gain | Plantar foot R | Plantar foot L | Yes |
11 | 77 | F | 4 | Polyneuropathy | Chemical induced PNP | Both feet and hands | Allodynia to touch | Mechanical gain | Dorsum foot R | Upper arm R | No |
12 | 70 | F | n/a | Polyneuropathy | Chemical induced PNP | Both feet | Pinprick hyperalgesia | Mechanical gain | Dorsum foot R | Ventral forearm R | n/a |
13 | 72 | F | n/a | Polyneuropathy | Diabetic PNP | Both feet | Hypoaesthesia to cold | Thermal loss | Dorsum foot R | Ventral forearm R | n/a |
14 | 49 | M | 22 | Mononeuropathy | Lesion peroneal nerve | Lateral lower leg and dorsal foot L | Hypoaesthesia to cold Hypoaesthesia to touch Pinprick hypoalgesia |
Thermal loss Mechanical loss |
Dorsum foot L | Dorsum foot R | n/a |
15 | 63 | M | 11 | Polyneuropathy | Guillain-Barré syndrome | Both feed, hand R | Hypoaesthesia to cold Hypoaesthesia to touch Pinprick hypoalgesia |
Thermal loss Mechanical loss |
Dorsum foot L | Ventral upper leg L | No |
16 | 51 | M | 4 | Radiculopathy | Root L5 | Both feet | Hypoaesthesia to cold Hypoaesthesia to touch Pinprick hypoalgesia |
Thermal loss Mechanical loss |
Dorsum foot L | Dorsal hand L | No |
17 | 57 | M | 13 | Polyneuropathy | Idiopathic SFN | Both feed | Hypoaesthesia to touch Pinprick hyperalgesia |
Mechanical loss Mechanical gain |
Dorsum foot L | Upper arm L | No |
18 | 42 | F | 1.5 | Polyneuropathy | Inflammatory SFN | Both legs | Hypoaesthesia to cold Hypoaesthesia to touch Pinprick hyperalgesia |
Thermal loss Mechanical loss Mechanical gain |
Dorsum foot R | Dorsal forearm R | No |
19 | 38 | F | 3 | Mononeuropathy | Lesion peroneal nerve | Lower leg and foot L | Hyperesthesia to cold Hypoaesthesia to touch Pinprick hyperalgesia |
Thermal gain Mechanical loss Mechanical gain |
Dorsum foot L | Ventral upper leg L | No |
20 | 57 | m | 6 | Polyneuropathy | Idiopathic PNP | 1st to 3rd toes bilateral | Hypoaesthesia to cold Dysaesthesia to touch Pinprick hypoalgesia |
Thermal loss Mechanical gain Mechanical loss |
1st toe R | Lower leg R | No |
21 | 55 | F | 8 | Polyneuropathy | Guillain-Barré syndrome | Both lower legs and feet | Anaesthesia to cold Dysaesthesia to touch Pinprick hypoalgesia |
Thermal loss Mechanical gain Mechanical loss |
Dorsum foot R | Ventral upper leg R | Yes |
22 | 56 | M | 0.5 | Polyneuropathy | Guillain-Barré syndrome | Foot L | Hypoaesthesia to cold Allodynia to touch Pinprick hypoalgesia |
Thermal loss Mechanical gain Mechanical loss |
Dorsum foot L | Shoulder L | Yes |
23 | 64 | M | 0.5 | Mononeuropathy | Lesion radial nerve | Radial nerve distribution hand R | Hypoaesthesia to cold Dysaesthesia to touch Pinprick hypoalgesia |
Thermal loss Mechanical gain Mechanical loss |
Radial nerve distribution hand R | Dorsal forearm L | Yes |
24 | 63 | M | 2 | Polyneuropathy | Diabetic SFN | All toes bilateral | Hypoaesthesia to cold Dysaesthesia to touch Pinprick hypoalgesia |
Thermal loss Mechanical gain Mechanical loss |
1st toe L | Upper arm L | No |
25 | 53 | F | 4 | Mononeuropathy | Lesion saphenous nerve | Saphenous nerve distribution R | Hypoaesthesia to cold Allodynia to touch Pinprick hyperalgesia |
Thermal loss Mechanical gain |
Medial lower leg R | Medial lower leg L | No |
26 | 51 | M | 32 | Plexopathy | arm plexus lesion lower part | Ulnar nerve distribution L | Anaesthesia to cold Allodynia to touch Pinprick hyperalgesia |
Thermal loss Mechanical gain |
4th finger dorsal L | 4th finger dorsal L | No |
27 | 63 | F | 6 | Radiculopathy | Root L5 | L5 dermatome lower leg L | Hypoaesthesia to cold Dysaesthesia to touch Pinprick hyperalgesia |
Thermal loss Mechanical gain |
Ventro-lateral lower leg L | Ventral upper leg L | No |
28 | 61 | F | 12 | Polyneuropathy | Idiopathic SFN | Both feet | Hypoaesthesia to cold Allodynia to touch Pinprick hyperalgesia |
Thermal loss Mechanical gain |
Dorsum foot R | Ventral upper leg R | Yes |
29 | 61 | M | 4 | Radiculopathy | Root L5 | L5 dermatome R | Hypoaesthesia to cold Dysaesthesia to touch Pinprick hyperalgesia |
Thermal loss Mechanical gain |
Dorsum foot R | Dorsum foot L | No |
30 | 42 | M | 0.5 | Radiculopathy | Root L4 | Ventro-medial lower leg R | Hypoaesthesia to cold Allodynia to touch Pinprick hyperalgesia |
Thermal loss Mechanical gain |
Ventro-medial lower leg R | Radial forearm R | No |
31 | 23 | M | 2 | Polyneuropathy | Idiopathic SFN | Both feet | Dysaesthesia to touch Pinprick hyperalgesia |
Mechanical gain | Dorsum foot R | Ventral upper leg R | No |
32 | 61 | M | 6 | Mononeuropathy | Lesion ulnar nerve | Ulnar nerve distribution L | Allodynia to touch Pinprick hyperalgesia |
Mechanical gain | Dorsal ulnar hand L | Dorsal ulnar hand R | Yes |
33 | 48 | M | 5 | Radiculopathy | Root L5 | 1st toe L | Dysaesthesia to touch Pinprick hyperalgesia |
Mechanical gain | 1st toe L | Ventral upper leg L | No |
Patients’ etiology of neuropathy, sensory profile, test areas of affected (neuropathic/painful) and non-affected (control) skin sites, and presence of lidocaine 5% patch analgesia defined as reduction of acute (spontaneous) pain at visit by NRS values exceeding 1. Note that 5 patients did not return the questionnaire and in 1 patient the sensory profile was not assessed (n/a).