Table 1.

The summary of animal and clinical studies regarding anti-hypertension effects of nettle and related mechanisms

Type of Study	Type of animal	Dosage of Nettle Extract	Duration of Study	Induction of hypertension	Main Outcomes	Mechanisms	Ref.
Animal	rat	4 mg/kg/h or 24 mg/kg/h	1.25 hr	0.9% NaCl	↓arterial blood pressure	↑diuresis and natriuresis	(38)
	rat	200 mg/kg/day	4 weeks		↓cardiac index ↓systolic and diastolic blood pressure		(37)
	rat	1, 3, 10, 30 and 50 mg/kg	6 weeks	high-salt (8 % NaCl) diet	↓mean arterial pressure	calcium channel blocking effects, nitric oxide (NO)-mediated vasorelaxation	(42)
	rat	1 and 2 g/l	30 min		↓blood pressure	bradycardia	(43)
Human	___	300 mL/day	16 weeks	___	↓blood pressure		(103)
	___	100 mg/kg/day	8 weeks	___	↓systolic blood pressure		(46)