FIGURE 7.

MCMV reactivation occurs in old mice during WNV infection, and is associated with increased mortality. Numbers on x‐axis indicate dose of WBI in youth in Gy. All mice MCMV(+), 19 months = MCMV(+) and non‐RWN‐vaccinated. (a) Percentage of Ki‐67 hi CD8 T cells within the m139 tetramer‐specific population in PBMC at various time points in late life. (b) Geometric granzyme B MFI within the m139 tetramer‐specific PBMC population at 19 months or on day 8 post‐WNV infection. ANOVA of 19 months = ns. Shown is the result of Bonferroni post‐test between radiation groups. (c) Geometric MFI of granzyme B in mice from the MCMV(+) 4Gy group in m139 tetramer‐specific PBMC population, stratified between mice that survived and mice that perished from WNV challenge