Small GTPases involved in semaphorin 3A signaling in immune cells

Receptor from Nrp-1/PlexA complex	Cell type	Signaling molecules	Function	References
Nrp-1	human T lymphocytes	Rap1	inhibition of proliferation and cytokine production	[13]
PlexA1	mouse DCs	Rho/ROCK-kinase	maintaining the ability of DCs to stimulate T cells*	[14]
Nrp-1/PlexA1	mouse DCs	RhoA/ROCK-kinase	enhancement of transmigration across lymphatic endothelium	[16]
Nrp-1	mouse macrophages	RhoA/ROCK-kinase	stimulation of macrophage migration	[17]
PlexA4	mouse macrophages	Rac1	upregulation of LPS-induced production of inflammatory cytokines	[15]
Nrp-1	mouse macrophages	downregulation of M-CSF-activated RhoA pathway	suppression of M-CSF-induced migration	[18]

* Direct semaphorin 3A involvement is not shown, but is supposed to be.