Table 3.
Composite primary outcome and its components during the 5-year follow-up
| Targeted therapy (N = 107) | Conventional therapy (N = 109) | P-value | |
|---|---|---|---|
| Composite outcomea | 20 (19%) | 15 (14%) | 0.353 |
| Individual componentsb | |||
| Cardiovascular death | 3 | 1 | |
| Arrhythmic | 1 | 0 | |
| Non-arrhythmic | 1 | 0 | |
| Stroke | 1 | 1 | |
| Hospital admission for heart failure | 3c | 3 | |
| Stroke | 3 | 2 | |
| Ischaemic stroke (1 fatal) | 3 | 0 | |
| Haemorrhagic (1 fatal) | 0 | 2 | |
| Systemic embolism | 1 | 1 | |
| Myocardial infarction | 5d | 3 | |
| Percutaneous coronary intervention | 3 | 3 | |
| Coronary artery bypass graft | 2 | 2 | |
| Bleeding | 7e | 3 | |
| Life-threatening arrhythmic events | 1 | 0 | |
| Pacemaker | 3 | 2 | |
| Implantable cardioverter-defibrillator | 1 | 0 | |
| Cardiac resynchronization therapy defibrillator | 0 | 0 |
Data are presented as number of patients (%).
Time to first cardiovascular event according to the RACE 3 protocol definition: Composite of death from cardiovascular causes and cardiovascular morbidity including hospitalization for heart failure, stroke, systemic embolism, myocardial infarction, percutaneous coronary intervention, coronary artery bypass graft, bleeding, life-threatening arrhythmic events, pacemaker, implantable cardioverter defibrillator or cardiac resynchronization therapy defibrillator.
Individual components can contain multiple cardiovascular events per patient. However, if 1 patient has a certain cardiovascular event multiple times (for example multiple hospitalizations for heart failure) only 1 event is presented in this table.
Total amount of heart failure hospitalization was 12 in 3 patients; 1 patient had 7 hospitalizations, 1 had 3, and 1 had 2.
Total amount of myocardial infarctions was 9 in 8 patients; 1 patient had 2 myocardial infarctions.
Total amount of bleedings was 13 in 10 patients; 1 patient had 3 bleedings, 1 patient had 2.