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. 2022 Jul 15;132(14):e150097. doi: 10.1172/JCI150097

Figure 8. Treatment with bacteriophage against Shigella sp. PIB improves constipation symptoms.

Figure 8

(A) Plaque morphology of an isolated Shigella sp. PIB phage from sewage water. (B) Restriction enzyme analysis for 3 phages. (C) Typical image of PIB medium after specific phage administration. Blank, LB only. (D) Growth curve of PIB with or without Shigella phages (n = 4). (E) Fecal PIB in the indicated groups of mice as assayed by PIB2013. (F) Fecal DPA levels in the indicated mouse groups (n = 5). (G) GTT time for mice with or without PIB-specific phages (CTR, n = 14; PIB, n = 14; PIB + phage, n = 15). Data are presented as mean ± SD. **P < 0.01 (1-way ANOVA Tukey’s multiple-comparison test).