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. 2022 Jul 15;132(14):e157504. doi: 10.1172/JCI157504

Figure 10. Transcriptomic analyses of the ISR in C10-mutant mice.

Figure 10

(A) Microarray data on hearts from 14-week-old C10G58R versus C10WT mice and 20-week-old C10S59L versus C10WT mice, all on the OMA1+/– background. Each column represents a mouse, and q values represent genome-wide significance. *q < 0.05. (B) Microarray data for 33-week-old C10G58R mouse hearts on the OMA1+/– background treated with either a nontargeting control ASO or an OMA1 ASO. Each column represents a mouse, and q values represent genome-wide significance. *q < 0.01. (C) GSEA of reactome pathways for the listed comparisons. Pathways shown are all the pathways with a q value of less than 0.025 in the C10G58R OMA1 ASO versus control ASO comparison. (D) Effect of OMA1 ASO on the expression of G58R DEGs identified in the comparison from A. See also Supplemental Figure 13 and Supplemental data sets 3 and 4.