Table 2:
Comparison of SRCA patients due to opioids/sedatives versus other substance-related cardiac arrests.
| Opioid/Sedative Related (N=69) |
Not Opioid/Sedative Related (N=17) |
P-Value | |
|---|---|---|---|
| Age, years | 42 ± 13 | 40 ± 16 | P = 0.52 |
| Sex, female (%) | 21/69 (30%) | 4/17 (24%) | P = 0.77 |
| Non-Shockable rhythm, yes (%) | 62/69 (90%) | 15/17 (88%) | P = 1.0 |
| TTM, yes (%) | 57/69 (83%) | 15/17 (88%) | P = 0.73 |
| Witnessed, yes (%) | 24/69 (35%) | 8/17 (47%) | P = 0.41 |
| Hospital Transfer, yes (%) | 17/69 (25%) | 8/17 (47%) | P = 0.08 |
| Post-ROSC GCS, median [IQR] | 3 [3-3] (N=66) | 3 [3-3] (N=15) | P = 0.77 |
| Pupillary Light Reflex, present (%) | 21/63 (33%) | 8/13 (62%) | P = 0.07 |
| Corneal Reflex, present (%) | 8/60 (13%) | 0/13 (0%) | P = 0.34 |
| Cough reflex, present (%) | 11/50 (22%) | 4/13 (31%) | P = 0.49 |
| Gag reflex, present (%) | 17/58 (29%) | 3/11 (27%) | P = 1.00 |
| Imaging | |||
| Time-to-first scan, days median [IQR] | 0 [0-1] | 0 [0-1] | P = 0.45 |
| Multiple scans, yes (%) | 51/69 (74%) | 13/17 (76%) | P = 1.00 |
| Severe Cerebral Edema, yes (%) | 31/69 (45%) | 5/17 (29%) | P = 0.28 |
| Time-to-Severe edema, days median [IQR] | 2 [0-3] (N=31) | 2 [0-3] (N=5) | P = 1.00 |
| Early Severe Cerebral Edema, yes (%) | 15/69 (22%) | 2/17 (12%) | P = 0.50 |
| Cortical injury, yes (%) | 51/69 (74%) | 11/17 (65%) | P = 0.55 |
| Time-to-Cortical Injury, days median [IQR] | 2 [0-3] (N=51) | 3 [1-4.5] (N=11) | P = 0.24 |
| Early Cortical Injury yes (%) | 23/69 (33%) | 4/17 (24%) | P = 0.56 |
| Outcomes | |||
| Poor outcome, yes (%) | 57/69 (83%) | 10/17 (59%) | P = 0.0497 |
| In-hospital death, yes (%) | 55/69 (80%) | 10/17 (59%) | P = 0.11 |
| Cause of Death: | |||
| Brain Death (%) | 11/55 (20%) | 1/10 (10%) | P = 0.67 |
| Cardiac Death (%) | 2/55 (3.6%) | 0/10 (0%) | P = 1.0 |
| WLST (%) | 42/55 (76%) | 9/10 (90%) | P = 0.68 |
| Time to death, days median [IQR] | 5 [3-7] (N=55) | 5 [4-6] (N=10) | P = 0.79 |
GCS = Glasgow Coma Scale, NA = Not Applicable, NS = Not selected variable, ROSC = Return of Spontaneous Circulation, TTM = Targeted Temperature Management, WLST = Withdrawal of Life Sustaining Treatment.