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. 2022 Jul 7;2022:3862122. doi: 10.1155/2022/3862122

Figure 3.

Figure 3

HUCMSCs induced the miR-100-5p expression by methylation miR-100-5p expression (a), METTL3 and METTL14 mRNA expression (b, c), RIP-PCR assays performed by using m6A anti-body (d), depletion either METTL3 or METTL14 led to m6A modification level (e), and si-METTL3 or si-METTL14 resulted in downregulation of miR-100-5p level (f). Control: control group; low/med/high: low/med/high of the HUCMSC group. METTL3 or METTL14: METTL3 upregulation or METTL14 upregulation group. ∗∗p < 0.01 compared with control or negative control group.