Fig. 3.
Weight loss-adjusted changes in cardiometabolic health markers from baseline by age group (n=2223). Values are estimated marginal mean (95% CI) changes from baseline in FPG (a), 2 h plasma glucose (b), HbA1c (c), triacylglycerol (d), HDL-cholesterol (e), LDL-cholesterol (f), SBP (g) and DBP (h). Younger adults: 25–45 years; middle-aged adults: 46–54 years; older adults: 55–70 years. Analyses were performed using a linear mixed model including sex, age, ethnicity, baseline BMI, baseline smoking status, baseline alcohol consumption, baseline values of the outcome being considered, time-varying percentage weight loss from baseline, baseline energy intake and PA, time-varying changes in energy intake and PA from baseline, intervention arm, time and interaction of time and age group as covariates and participant identifier and intervention centre as random effects. Post hoc multiple comparisons with Bonferroni adjustment were performed to compare age groups at each time point. Older vs younger adults *p<0.05, **p<0.01 and ***p<0.001; middle-aged vs younger adults †p<0.05, ††p<0.01 and †††p<0.001; older vs middle-aged adults ‡p<0.05, ‡‡p<0.01 and ‡‡‡p<0.001