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. 2022 Jun 1;78(8):1289–1299. doi: 10.1007/s00228-022-03336-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Intestinal CYP3A4 metrics. Correlation between (a) midazolam absolute bioavailability^a and 4βOHC concentrations, (b) apparent oral midazolam clearance (CL/F)^a and 4βOHC concentrations, (c) jejunum CYP3A4 concentration^b and 4βOHC concentrations, and (d) clearance intrinsic for midazolam 1′-hydroxylation in human intestinal microsomes^c and 4βOHC concentrations. Spearman’s rho (ρ) is the correlation coefficient, and the p value is from the Spearman rank correlation analysis. ^aAvailable in 92 patients (patients with obesity = 74, normal to overweight individuals = 18). ^bAvailable in 37 RYGB-patients. ^cAvailable in 20 RYGB-patients. Abbreviations: CL_int,u, clearance intrinsic unbound; CYP, cytochrome P450; HIM, human intestinal microsomes; 4βOHC, 4-beta hydroxycholesterol