. 2001 May;67(5):2037–2043. doi: 10.1128/AEM.67.5.2037-2043.2001

TABLE 1.

Characteristics of coumermycin A₁-resistant B. hyodysenteriae strains

Strain	Coumermycin A₁ MIC (μg/ml)^a	Mutation^b
Strain	Coumermycin A₁ MIC (μg/ml)^a	gyrB codon	GyrB amino acid
120B	25–100	T₂₃₂GT	Cys₇₈
235C	50–100	A₂₃₂GT	Ser₇₈
435A	50–100	A₂₃₂GT	Ser₇₈
235E	50–100	G₄₉₆CT	Ala₁₆₆
235F	25–50	NC	NC

MICs (in micrograms of coumermycin A₁/per milliliter of TSB agar) are based on two to four determinations for each strain. B. hyodysenteriae wild-type strain B204 had a coumermycin A₁ MIC of 0.1 to 0.25 μg/ml.

The subscript numbers refer either to nucleotide base positions in the gyrB coding sequences or to the corresponding amino acid positions in the predicted GyrB proteins. The corresponding wild-type strain B204 base positions are G₂₃₂GT (Gly₇₈) and A₄₉₆CT (Thr₁₆₆). NC, no change. Strain 235F and four other coumermycin-resistant strains (235C, 235D, 635F, and 420A) had gyrB sequences identical to that of wild-type strain B204.