Table 1: Risk analysis of broad-spectrum antibiotic pre-exposure in humans.

Adjusted risk ratios for the association between broad-spectrum antibiotic pre-exposure and developing invasive candidiasis (Odds ratio), broad-spectrum antibiotic pre-exposure and 31-day mortality post-invasive Candida infection (hazards ratio), and broad-spectrum antibiotic pre-exposure and developing a systemic bacterial co-infection within 31 days after developing invasive candidiasis (where 31-day mortality was treated as a competing risk, subdistribution hazard ratio). See main text and methods section for total numbers of patients and details of co-variates used. CI, confidence interval.

Clinical variable	Adjusted risk ratio	Lower CI	Upper CI
Invasive candidiasis	1.13	1.03	1.25
Mortality post-invasive candidiasis	1.18	1.02	1.36
Bacterial co-infection, post-invasive candidiasis	1.20	0.90	1.60