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Fatty acid binding parameters of wild-type cytoglobin and mutants.
| Cytoglobin | Oleic acid | Octanoic acid |
|---|---|---|
| KD (μM) | KD (μM) | |
| Wild-type | 2.3 ± 1.0a | 1590 ± 740 |
| H81A | 24 ± 2 | 1520 ± 890 |
| H81Q | 46 ± 8 | 250 ± 10 |
| H81L | 36 ± 13 | 950 ± 80 |
| H81W | 32 ± 10 | 140 ± 10 |
| R84E | 170 ± 90 | n.d. |
| T91D | 5.7 ± 1.4 | n.d. |
| V105Y | 4.8 ± 3.2 | n.d. |
| L108Q | 14 ± 3 | n.d. |
| K116E | 62 ± 23 | 185000 ± 13000 |
Dissociation constants determined at 25°C in 100 mM sodium phosphate, pH 7.4. All values from this work except
from [8].
